Data from: Single cell RNA-seq data of E18 fetal thymocytes from HEB Vav-iCre and Id3-KO mice and their wild type littermate counterparts
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https://datadryad.org/dataset/doi:10.5061/dryad.08kprr5cq
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资源简介:
γδ T cells that produce IL-17 (γδT17) play essential roles in barrier
immunity and autoimmunity, but the gene networks that install their
functions are not well understood. To understand how HEB and Id3
regulate γδT17 cell development, we conducted single-cell RNA-sequencing
on fetal thymic γδ T cells from Tcf12-deficient (HEB cKO) and Id3 knockout
(Id3-KO) E18 embryos. Four datasets were generated. The first two consist
of WT and HEB cKO datasets derived from sorted gamma-delta T cells. The
second two consist of WT and Id3-KO datasets derived from magnetically
enriched for CD4/CD8-negative cells. HEB datasets were generated with 10X
Genomics 5' chemistry, and Id3 datasets were generated with 10X
Genomics 3' chemistry. Raw sequence files were processed using Cell
Ranger to generate matrix files, which have been uploaded here. We also
include R-markdown files (RMD) and R-markdown HTML output files to provide
code and programs used for the data analysis shown in the associated
paper.
提供机构:
Dryad
创建时间:
2025-12-08



