A mouse model for embryonic mosaicism during preimplantation development
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https://www.ncbi.nlm.nih.gov/sra/SRP304798
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资源简介：
The study describes a mouse model for chromosome breakage in human embryos. Mouse embryos are treated with aphidicolin in late G2 phase of the first cell cycle to inhibit completion of DNA replication and induce chromosome fragility. After one or several transitions through mitosis, chromosomal content is analyzed through sequencing. Sites of G2 DNA synthesis are fragile in human embryos, resulting in spontaneous segmental aneuploidies. Inhibition of DNA replication completion in mouse embryos reproduces these defects.
创建时间：
2022-07-14
