Additional file 1 of Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis

Additional file 1: Table S1. Details of the instruments used as proxy risk factors for longevity. Table S2. Description of independent exposure GWAS used in validation. Table S3. Estimates of inverse variance weighted method for significant associations between genetically predicted exposures and longevity. Table S4. Sensitivity analysis results for the metabolites identified in secondary analysis. Table S5. Pleiotropy and heterogeneity analyses for the association between exposures and Alzheimer's disease in secondary analysis. Table S6. The Mendelian randomization association of individual SNPs of screening traits in primary analysis. Table S7. Mendelian randomization results of validation using independent exposure GWAS. Table S8. Mendelian randomization results of validation using dataset of 90th percentile longevity. Table S9. Mendelian randomization results of validation using dataset of 99th percentile longevity. Table S10. List of exposures in the present study. Table S11. Exposures identified significantly and suggestively associated with 90th percentile longevity in primary analyses. Table S12. Exposures identified significantly and suggestively associated with 99th percentile longevity in secondary analyses.