HDAC4 controls senescence and aging by safeguarding the epigenetic identity and  ensuring the genomic integrity
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Purpose: Define the epigenetic program of HDAC4Outcome: HDAC4 controls the H3K27me3 of repetitive elements of retroviral origin (ERVs) and the H3K27 deacetylation of typical and super-enhancers found to be activated during senescence. The former response is due to the remodeling of the chromatin that sorrounds ERVs, while the latter is directly mediated by HDAC4 binding to the chromatin and the local deacetylation.
提供机构：
Università degli Studi di Udine
创建时间：
2022-02-20
