Decreased levels of ASRGL1 in ALS patients associate with TDP-43 proteinopathy. ASRGL1 immunostaining of brain samples. Motor cortex samples (Broadman area 6) of ALS individuals (n=4), multiple sclero
ABSTRACT INTRODUCTION: TDP-43 is an intranuclear protein involved in many cellular processes. When altered, it shows a change in pattern of distribution, as well as in functioning, throughout the Cent