Conformational trapping in a membrane environment: a regulatory mechanism for protein activity?
收藏PubMed Central1996-06-11 更新2026-05-02 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC39154/
下载链接
链接失效反馈官方服务：
资源简介：
Functional regulation of proteins is central to living organisms. Here it is shown that a nonfunctional conformational state of a polypeptide can be kinetically trapped in a lipid bilayer environment. This state is a metastable structure that is stable for weeks just above the phase transition temperature of the lipid. When the samples are incubated for several days at 68 degrees C, 50% of the trapped conformation converts to the minimum-energy functional state. This result suggests the possibility that another mechanism for functional regulation of protein activity may be available for membrane proteins: that cells may insert proteins into membranes in inactive states pending the biological demand for protein function. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-06-11
