MATK (CSK homologous kinase) binds phosphorylated ERBB2

MATK (also known as CHK or CSK homologous kinase) binds to ERBB2 through phosphorylated tyrosine residue Y1253 in the C-tail of ERBB2 and, through an unknown mechanism, inhibits ERBB2 downstream signaling.

MATK（亦称CHK或CSK同源激酶）通过与ERBB2的C端尾部的磷酸化酪氨酸残基Y1253结合，并借助一种未知的机制，抑制ERBB2下游信号传导。