Herpes simplex virus type 1 reshapes the host chromatin architecture via transcription machinery hijacking [RNA-seq]

To discover the mechanism by which herpes simplex virus type 1 (HSV-1) drastically reshapes the host cell transcriptional patterns during infection, we performed RNAseq. We infected A549 cells with HSV-1, and analized host and viral expression at 1, 3 and 8 hours post infection. We report both a drastical human transcription shutoff parallel with an increase in viral transcription. RNAseq samples from A549 cells and A549 cells infected with Herpes Simplex Virus type 1 (HSV1), at 1, 3 and 8 hours post infection.