The expression profile of miRNA in the testis of STZ-induced diabetic rats

The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysfunction. We thus explored the role of miRNAs in diabetic testicular damage, and revealed that they could serve as effective prevention and treatment therapeutic targets.Streptozotocin (STZ) was used to generate a rat model of type 2 diabetes. Rat testicular tissues were used for miRNA sequencing. we identified 19 differentially expressed miRNAs in the testes of diabetic rats. Testicular tissues miRNA profiles of rat after 8 weeks of STZ-induced diabetes were generated by high throughput sequencing using Illumina Hiseq 3000.