Transcriptome analysis of mesothelioma induced by intraperitoneal injections of ferric saccharate in rats

Iron plays an important role in oxidative tissue damage and subsequent carcinogenesis. Iron deposition in the peritoneum causes neoplastic changes. Here we used gene expression microarrays to find common genetic alterations in a rat model by repeated intraperitoneal injections of ferric saccharate. Gene expression microarray revealed the expression of uromodulin (Umod) is increased in mesothelioma approximately 250-fold.铁在组织氧化性损伤及后续的癌变进程中发挥关键作用。腹膜内铁沉积可引发肿瘤性病变。本研究通过对大鼠模型反复腹腔注射糖酸铁，利用基因表达微阵列（gene expression microarrays）技术探寻该模型中共有的遗传改变。基因表达微阵列分析显示，间皮瘤中尿调节素（uromodulin, Umod）的表达水平上调约250倍。