PLA2G4E Orchestrates optimal Synapse Development and Neuronal Maturation [shPLA2G4E]

Constitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity markers compared to wild-type counterparts.We performed gene expression profiling analysis os neurons lacking PLA2G4E to study the function of this enzyme in synaptic transmission. Overall design: Comparative gene expression profiling analysis of RNA-seq data obtained from neuronal cultures treated with lentiviral particles expressing shRNA agains Pla2g4e or scrambled