Oxidative stress initiates hemodynamic change in CKD induced heart disease

Cardiovascular disease is highly prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of CKD-related deaths. The mechanisms underlying the detrimental impact of CKD on the heart are still incompletely understood, but CKD is associated with endocrinal, inflammatory and hemodynamic changes that impact the heart and may contribute to the development of uremic cardiomyopathy.