A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance through effects on the gut microbiota

NIAID Data Ecosystem2026-03-13 收录

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肠道微生物组肿瘤调控

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Castalagin polyphenol potentiates anti-PD-1 efficacy through a shift in the microbiome composition, reprogramming the tumor microenvironment

创建时间：

2022-01-21

KDM1B is an important regulator of cytokine signaling in the tumor immune microenvironment and response to immune checkpoint therapy (RNA-seq)

肿瘤免疫微环境

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Tumor microenvironment (TME) plays an important role in immune evasion and resistance to immune checkpoint therapy. Here, by using genetic, epigenetic, tumor biology and immunology approaches, we unra

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High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway. High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway

肿瘤免疫微环境

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In order to study the difference between high tumor burden and low tumor burden, we established MC38 tumor-bearing mice. We then performed gene expression profiling analysis using data obtained from R

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Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma. Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma

肿瘤免疫微环境分析

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Background:Acral melanoma (AM) has distinct characteristics as compared to cutaneous melanoma and exhibits poor response to immune checkpoint inhibitors (ICI). Tumor-intrinsic mechanisms of immune exc

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Intratumoral TFR cells curtail anti-PD-1 treatment efficacy

肿瘤免疫微环境

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Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a subs

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Table_1_Investigation of the efficacy and safety of cryoablation and intra-arterial PD-1 inhibitor in patients with advanced disease not responding to checkpoint inhibitors: An exploratory study.docx

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ObjectiveTo explore the effectiveness of cryoablation combined with arterial perfusion with programmed cell death protein 1 inhibitors in overcoming immune resistance in advanced solid cancers. Method

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A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance through effects on the gut microbiota

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