Optimization problems for various configurations of the VEP model.

The seizure propagation depends on the interplay between node dynamics (excitability) and network coupling (structure). The signals generated by VEP models on the brain region level are called source signals (see Eq 1). The measured signals from the electrodes are called sensor signals. To map the simulated sources from the brain regions to the sensors, the electromagnetic forward problem needs to be solved (see Eqs 2 and 3). Due to the sparse placement of electrodes, the gain (lead-field matrix) used for mapping the source to the sensors is not of full rank.