Supplementary Material for: JC virus-induced polyomavirus nephropathy - A rare complication late after kidney transplantation

Background: JC-Polyomavirus allograft nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only few cases described in the literature.
Case presentation: We present two cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of the kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adapted, but in both cases graft function progressively deteriorated.
Conclusions: Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered as possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.