Mutation spectra in CAN1 reporter.

aClasses of mutations characteristic for Polζ are indicated in bold.bParentheses indicate the number of sequenced isolates of each subclass.cRelative fraction of the isolates of each subclass among the total isolates sequenced.dFrameshift mutations are insertions and deletions of 1–5 nucleotides.eComplex mutations are more than one nucleotide change in a span of 10 nucleotides.fSlippage subclass includes deletions from −15 to −39 nucleotides and duplication of 27 nucleotides flanked by short direct repeats.g*indicates the classes demonstrating increased rates of mutagenesis due to the activity of Polζ.