PC is hydrolysed to 2-acyl LPC by PLA2[7]

At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolysed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.

在质膜内质网（ER）膜上，磷脂酰胆碱（PC）被胞浆磷脂酶A2α/β/δ/ε/ζ（PLA2G4A/B/D/E/F）（Ghomashchi 等人，2010年）水解，并由此切断其一条酰基链。此过程生成了2-酰基溶血磷脂酰胆碱（LPC）。胞浆磷脂酶A2酶不仅表现出PLA2水解活性，以形成1-酰基溶血磷脂，而且具有一定的PLA1活性，从而生成2-酰基溶血磷脂。