Crystal structure of the human METTL3-METTL14 in complex with compound 1 (AD-79)

Crystal structure of the human METTL3-METTL14 in complex with compound 1 (AD-79) Descriptor: 8-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-2-[6-(methylamino)pyrimidin-4-yl]-2,5,8-triazaspiro[3.5]nonan-6-one, ACETATE ION, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, ... Authors: Bedi, R.K, Dolbois, A, Caflisch, A. Deposit date: 2025-06-30 Release date: 2026-03-18 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Ligand-Induced Opening of a Cryptic Pocket in METTL14. Acs Bio Med Chem Au, 6, 2026