transcriptomic analysis of the effects of three MUFA-rich oils on hepatic glucose and lipid metabolism in mice

Scope: Olive oil, rapeseed oil, and lard are dietary fats that are rich in monounsaturated fatty acids. However, the effects of dietary oils enriched in MUFAs on hepatic lipid deposition have seldom been compared.Methods and Results: 90 eight-week-old C57BL/6J male mice were randomly divided into six groups and fed diets containing lard, rapeseed oil, or olive oil with a 10% or 45% fat energy supply for 16 weeks. Under high-fat conditions, the serum total cholesterol in the lard and olive oil groups were significantly higher than in the rapeseed oil group. The hepatic lipid contents in the olive oil group were higher than those in the other two groups. Compared with rapeseed oil, lard increased liver levels of arachidonic, palmitic, and myristic acid and decreased levels of eicosapentaenoic linolenic, and linoleic acid. Olive oil increased liver levels of docosatrienoic, arachidonic, oleic, and myristic acid, maltose, and fructose and decreased levels of eicosapentaenoic, linolenic, and linoleic acid.