SPO11
收藏rgd.mcw.edu2025-01-09 收录
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1315081
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资源简介：
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
减数分裂重组及染色体分离过程依赖于成对的染色体同源区段中双链断裂（DSBs）的形成。在酵母的减数分裂过程中，一种减数分裂重组蛋白通过共价键与DSBs的5'端相连接，其对DSBs的形成至关重要。该基因编码的蛋白在序列及保守结构特征上与酵母的减数分裂重组蛋白相似，并归属于TOP6A蛋白家族。针对此基因，已发现多个转录变体，其中仅两种的全长性质得到了描述。[资料来源：RefSeq，2008年7月]
提供机构：
Rat Genome Database
