Ablation of SOX10 impaired the differentiation and migration potential of neural crest derived from human pluripotent stem cells

Here, control human pluripotent stem cells (hiPSCs) and SOX10 knockout (SOX10 KO) hiPSCs were induced to differentiate to neural crest stem cells (NCSCs). We sequenced mRNA samples of differentiated cells at day 7 during NCSC differentiation to generate the gene expression profiles of these cells. 6 samples from differentiated cells at day 7, including control hiPSC-derived cells (WT1-1, WT1-2), SOX10 KO1 hiPSC-derived cells (KO1-1, KO1-2), and SOX10 KO2 hiPSC-derived cells (KO2-1, KO2-2) were analyzed.