Population-based therapeutic efficacy of albendazole against soil-transmitted helminth infections in three study sites.

The population-based therapeutic efficacy is expressed as the egg reduction rate, ERRP, defined as the reduction in the arithmetic mean fecal egg count (FEC) following administration of a single 400 mg oral dose of albendazole (see Eq (1)). The FECs were based on duplicate Kato-Katz thick smear. Ntot represents the total number of participants screened for STH infection; N+ the number of participants identified as infected at baseline by any of the four diagnostics (duplicate Kato-Katz thick smear, Mini-FLOTAC, FECPAKG2 and qPCR) and, NKK+ the number of participants infected at baseline by duplicate Kato-Katz thick smear. The 95% confidence intervals (CIs) were calculated using a non-parametric block bootstrap approach [23].