CSF pharmacokinetic parameters of idursulfase IV and IT at CM level.

AUCinf, area under the concentration-time curve extrapolated to infinity; AUC0-t, area under the concentration-time curve from time 0 to the last sampling time; CL, total clearance; CM, cisterna magna; Cmax, maximum observed concentration; CSF, cerebrospinal fluid; I2S, iduronate-2-sulfatase; IT-L, intrathecal lumbar; IV, intravenous; MRTinf, mean residual time derived from time 0 to infinity; na, not available; SD, standard deviation; t½, terminal half-life; Tmax, time of occurrence of Cmax; Vss, volume of distribution at steady state; Vz, volume of distribution during terminal phase; λZ, apparent terminal rate constant.aUnits were ml/kg for IV and ml for IT-L dosingbn = 3cUnits were ml/h/kg for IV dosing and ml/h for IT-L.CSF pharmacokinetic parameters of idursulfase IV and IT at CM level.