Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://figshare.com/articles/dataset/Identification_of_Triazolothiadiazoles_as_Potent_Inhibitors_of_the_dCTP_Pyrophosphatase_1/4653970
下载链接
链接失效反馈官方服务：
资源简介：
The dCTP pyrophosphatase 1 (dCTPase)
is involved in the regulation of the cellular dNTP pool and has been
linked to cancer progression. Here we report on the discovery of a
series of 3,6-disubstituted triazolothiadiazoles as potent dCTPase
inhibitors. Compounds 16 and 18 display
good correlation between enzymatic inhibition and target engagement,
together with efficacy in a cellular synergy model, deeming them as
a promising starting point for hit-to-lead development.
创建时间：
2017-02-15
