Role of Yap/Taz in mouse embryonic stem cells

Here, we show that the loss of Yap/Taz function does not affect the undifferentiated status of the ESCs but these factors play a pivotal role in the maintenance of the pluripotent cells by keeping the process of apoptosis at bay. RNA-seq analysis of wildtype, Taz knockout, and Yap/Taz double knockout ESCs