Chromatin accessibility and transcriptome changes in injured retinal ganglion cells (RGCs) after Arid1a deletion

To gain a deeper insight into roles of Arid1a in injured retinal ganglion cells (RGCs), we performed ATAC-seq and RNA-seq to analyze the genome-wide changes of chromatin accessibility and transcriptome changes before and after Arid1a deletion in RGCs of the adult mouse using Cre-lox system. Overall design: Total RNA was extracted from WT and Arid1a-cKO RGCs and generated by deep sequencing, in three biological replicates, using Illumina HiSeq X Ten. ATAC-seq was sequenced in two biological replicates using RGCs.