Brown rice-specific bioactive substance, γ-oryzanol ameliorates fuel dysmetaborism, but it is hardly absorbed form the intestine. To increase the efficiency of its absorption, we therefore challenged

NIAID Data Ecosystem40

Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss

代谢疾病治疗

药物机制研究

The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone micr

Figshare2017-07-18 更新20

Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut

肠道脂噬调控

代谢疾病治疗

Lysosome-mediated macroautophagy, including lipophagy, is activated under nutrient deprivation but is repressed after feeding. We show that, unexpectedly, feeding activates intestinal autophagy/lipoph

NIAID Data Ecosystem80

Table 2_Orexinergic pathway as a potential therapeutic candidate for the modulation of glucose homeostasis.xlsx

葡萄糖稳态调控

代谢疾病治疗

BackgroundGlucose homeostasis is regulated by both central and peripheral systems to maintain metabolic stability during periods of feeding, fasting, and stress. Orexins A and B, hypothalamic neuropep

NIAID Data Ecosystem40

Treatments and management characteristics of patients with MAS.

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