Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

The .zip files contain the fastq files for the cell line data published in DOI: 10.1126/scitranslmed.3006086 plus results of analyzing these data. HK2_AA and HK2b-8d2 were exposed to AA (aristolochic acid I), and HK2_ctrl was an unexposed control. The .tsv files are VCF-like files with the mutations found in the exposed cells. spectrum_counts.txt are what are now called "SBS96" spectra -- counts of single base substitutions in the contexts of preceding and following bases. The PDF file has plots of these. (The HUC1 cells that were exposed did not show AA-related mutations.)