Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior

The ability to adapt previously learned behaviors is crucial for survival in dynamically changing environments. The hippocampus has been implicated in associative learning, but how hippocampus activity along its septotemporal axis contributes to flexible adaptation is unknown. Using in vivo Ca2+ recordings and functional inhibition of dorsal CA1 (dCA1) and ventral CA1 (vCA1) neurons in mice during complementary cognitive flexibility tasks, we find that dCA1 is engaged and functionally required during consolidation of a learned contingency both before and after a rule change, whereas vCA1 is uniquely recruited during, and necessary for, early adaptation to a new contingency. This vCA1-dependent adaptation relies on a perseverative error signal, which is encoded in vCA1 and required for behavior updating. These results highlight a novel division of labor within the hippocampus, in which vCA1 enables flexible adaptation when mismatches in expected and actual outcomes are detected, while dC..., , , ---

## Overview

This dataset contains behavioral and neural recordings supporting the manuscript:\
**“Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.”**

Data include z-scored ΔF/F (delta F over F) calcium signals and behavioral performance measures from mice performing **Y-maze**, **Barnes maze**, and **digging tasks**.\
Each Excel file corresponds to one figure in the paper, and each worksheet (tab) corresponds to one figure panel.\
All figures are fully reproducible using **MATLAB**, **GraphPad Prism**, or **Microsoft Excel**.

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## File Structure

### MATLAB Analysis Scripts

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