Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons

Data from Porniece, M., Baker, J., Ausfahl, C.D. et al. "Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons". Sci Rep 15, 35837 (2025). https://doi.org/10.1038/s41598-025-19800-2 Fiber photometry and linked behavioural data examining feeding-evoked response dynamics in hypothalamic satiety neurons. Food consumption-evoked responses in PVHMC4R neurons increase gradually during meal consumption to promote satiety, and disrupting this process drives massive obesity. These criticalsatiety neurons are strongly affected by a high-fat diet, yet the impact on their functional properties remains unknown. We used fiber photometry to track PVHMC4R neurons’ responses to the consumption of drops of milkshake in animals fed a chow diet or a high-fat diet (HFD), both after obesity was established and after its reversal.