Interaction between a high HR-HPV load and alcohol consumption on the risk of 1-year HR-HPV persistence.

†N w/wo persistence, the number of subjects with/without persistence; OR, odds ratio. 1)HPV load was classified as low (<100 relative light units [RLU]/positive control [PC]) or high (≥100 RLU/PC). 2)Multivariate logistic regression analysis was performed with adjustment for age as a continuous variable and for menopausal status, oral contraceptive use, smoking status, and number of children as categorical variables. Risk estimates were calculated with no alcohol consumption, alcohol consumption for <5 years, or alcohol consumption <15 g/day and a low HPV load combination as reference categories. 3), 4)The relative excess risk due to interaction (RERI) and synergy index (S) were calculated as described by Rothman et al. RERI>0 and S>1.0 indicate a synergistic effect between HR-HPV load and alcohol consumption behaviors.