Analysis of the senescence transcriptome in TRF2dBdM-induced senescence and replicative senescence [microarray]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE153922
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We stably infected IMR90 fibroblasts with lentiviral vectors expressing doxycycline-inducible TRF2dBdM or vector control. Cells were treated with 1mg/ml of doxycycline for 7 days to induce senescence in the cells expressing TRF2dBdM before collecting RNA. IMR90 cells, either young (passage 10, population doubling ~20) or old (passage 24, population doubling ~40-48) were also used as a model of replicative senescence. The transcriptomes were analyzed using RNA microarrays. 12 samples examined: 3 Empty vector (control), 3 TRF2dBdM (senescent), 3 young, 3 old.
创建时间：
2021-03-23
