Whole brains and frontal lobes of rat offsprings exposed perinatally to low doses of 2,2',4,4'-tetrabromodiphenyl ether

Analysis of developmental toxicity of environmental toxin 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) at the level of gene expression. Dams of Wistar rats were exposed to environmentaly relevant doses of BDE-47 at gestation and lactation. Gene expression in total brains and frontal lobes was analysed in offspring on postnatal day 10.本研究针对环境毒素2,2',4,4'-四溴二苯醚（2,2',4,4'-tetrabromodiphenyl ether，简称BDE-47）的基因表达层面发育毒性开展分析。实验以环境相关剂量的BDE-47对妊娠期及哺乳期的Wistar大鼠孕鼠进行染毒，于仔鼠出生后第10天，对其全脑与额叶的基因表达水平进行检测分析。