Local sensitivity analysis of the threshold of infection pthres, with respect changes in relevant model parameters.

Normalized sensitivity index (SI) of key biological parameters in the reduced 2-PDE model with respect to the threshold of infection (pthres), considered as the quantity of interest (QOI). The baseline values of the parameters are provided in parentheses. Positive and negative indices indicate parameters that increase or decrease the threshold, respectively. The sensitivity index was calculated by increasing each baseline quantity of the parameters of interest by 1%. The infection threshold is more sensitive to the per capita reproduction rate of infected and uninfected cohorts, followed by the release radius.