Hspa8 and ICAM-1 identified as damage-induced mediators of gd T cell activation

Here we identify a novel members of a gamma delta T cell "wound signature" that are upregulated following wounding and mediate the gamma delta T cell wound response. RNA-seq analysis of wounded and non-wounded epidermis was initially used to identify two new wound signature proteins (ICAM1 and HSPA8) Overall design: RNA-seq data was generated from mouse whole epidermis from non-wounded skin and 2-hours post-wounding