Tumor-derived Schwann-like cells promote neuroblastoma survival through secreted trophic factors

Neuroblastoma (NB) is comprised of a mixture of neuroblastic N-type cancer cells, and Schwannian stromal S-type cells. Sublines of N- and S-type cells were isolated from an early passage of SK-N-SH NB cell line. RNA-Seq analysis was conducted on slected N- and S-type cells in order to define their unique expression profiles. Overall design: An N-type cell line, NC3; and an S-type cell line, S3, was selected. RNA was extracted in duplicate and subjected to RNA-Sequencing analysis.