DHX30

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The family member encoded by this gene is a mitochondrial nucleoid protein that associates with mitochondrial DNA. It has also been identified as a component of a transcriptional repressor complex that functions in retinal development, and it is required to optimize the function of the zinc-finger antiviral protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

DEAD盒蛋白，其特征为保守的Asp-Glu-Ala-Asp（DEAD）基序，是推测的RNA解旋酶。它们在涉及RNA二级结构改变的一系列细胞过程中发挥作用，如翻译起始、核和线粒体剪接以及核糖体和剪接体的组装。根据其分布模式，该家族中的一些成员被认为参与胚胎发生、精子发生以及细胞的生长和分裂。本基因编码的家族成员是一种线粒体核质蛋白，与线粒体DNA相关联。它还被鉴定为视网膜发育中转录抑制复合体的一部分，并且是优化锌指抗病毒蛋白功能所必需的。此外，对于该基因还存在可变剪接的转录变体。[由RefSeq提供，2013年2月]