Harmonized datasets to support seroepidemiology of Trachoma for the elimination endgame

Trachoma is targeted for global elimination as a public health problem by 2030. Measurement of IgG antibodies in children is being considered for surveillance and programmatic decision-making. There are currently no guidelines for applications of serology, which represents a generalizable problem in seroepidemiology and disease elimination. We collated Chlamydia trachomatis Pgp3 and CT694 IgG measurements from 48 serosurveys, including surveys across Africa, Latin America, and the Pacific Islands to estimate population-level seroconversion rates (SCR) along a gradient of trachoma endemicity. , , , # Harmonized datasets to support seroepidemiology of Trachoma for the elimination endgame

[https://doi.org/10.5061/dryad.5qfttdzhx](https://doi.org/10.5061/dryad.5qfttdzhx)

## Description of the data and file structure

Overview

This repository includes harmonized data to support research on the seroepidemiology of trachoma and *Chlamydia trachomatis*, which were harmonized and made publicly available under the NIH-funded study: Seroepidemiology of trachoma for the elimination endgame [R01-AI158884](https://reporter.nih.gov/search/Vp1i0zHsQkOOzfYshpRgOQ/project-details/10181859).

We are currently making two datasets public: one with individual-level records (trachoma_serology_public_data_indiv_v4) and one with cluster-level records (trachoma_serology_public_data_cluster_v4). 

The cluster-level data were generated by summarising the individual-level data by evaluation unit and age. However, note that some additional data were only available at the cluster-level and not at the indiv..., All primary data were collected after obtaining informed consent from all participants or their guardians under separate, local human subjects research protocols in accordance with the Declaration of Helsinki. The data were de-identified using randomly generated integers to mask original variables.