Total Synthesis of (−)-Batrachotoxinin A: A Local-Desymmetrization Approach

An enantioselective
total synthesis of (−)-batracho­toxinin
A is accomplished based on a key photoredox coupling reaction and
the subsequent local-desymmetrization operation. After the expedient
assembly of the highly oxidized steroid skeleton, a delicate sequence
of redox manipulations was carried out to deliver a late-stage intermediate
on gram scaleand ultimately (−)-batracho­toxinin
A in an efficient manner.