CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron-19 5â²Â Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Results indicate that CRISPR/Cas9 gene editing of a suboptimal E19/I19 5Ⲡsplice site in the TOP2α gene results in circumvention of acquired drug resistance to etoposide and other TOP2-targeted drugs in a clonal K562 cell line by enhancing removal of intron 19 thereby decreasing formation of a truncated TOP2α/90 isoform and increasing expression of full-length TOP2α/170 in these resistant cells.
提供机构：
The Ohio State University
创建时间：
2022-02-20
