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Effect in MOLM-14 cells of 24hr cortistatin A treatment on gene expression

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NIAID Data Ecosystem2026-03-11 收录
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We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML proliferation. In this series, we examine the transcriptional effect on MOLM-14 cells of 24hrs exposure to CA. MOLM-14 cells were treated in triplicate with either DMSO or CA for 24hrs. RNA was harvested and hybridized to microarrays to assess transcriptional changes.

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2019-03-25
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