LCV analysis for bipolar affective disorder.

Bipolar affective disorder (BPAD) is a chronic psychiatric condition with high heritability (60–85%) and significant phenotypic variability, complicating its etiological understanding. Genome-wide association studies (GWAS) have revealed genetic overlaps with diverse traits, suggesting pleiotropy. This study aimed to identify shared genetic factors and infer causal relationships using large-scale GWAS data.BPAD GWAS summary statistics were obtained from the UK Biobank via the Complex Trait Genetics Virtual Lab (CTG-VL) platform. Genetic correlations with 1,504 traits were estimated using linkage disequilibrium score regression (LDSC), with quality filters ensuring heritability (h² > 0.05, p 0.6; FDR