Uptake and pharmacokinetics of [11C]methamphetamine in the various organs.

Measures correspond to: time to peak concentration (Peak time), time to half-peak clearance averaged across both groups and peak concentration (expressed as % dose per cc) and AUC for the time activity curves for the African Americans (AA) and for the Caucasians (C).*Unpaired Student t test (two tail) paThe plasma value was extrapolated to whole blood assuming a 55% plasma volume.bReflects the total weight of both left and right organs. Note that the total percent of organ accumulation is greater than 100%; this is because the times at which the peak uptake and the clearance occurs differs among the organs. The weight of the organs corresponds to the average weights recorded from male autopsies [37]; except in brain, which corresponds to weights obtained with MRI38.