Project 60: Bicomposite Nanotherapeutic Architecture for PDAC - Clinical Spatial Transcriptomics Validation Package (v6.0)
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This repository contains the computational pipeline, spatial datasets, and validation outputs supporting version 6.0 of Project 60. The data is derived from the NCBI GEO dataset GSE274103 (human pancreatic ductal adenocarcinoma - PDAC). It includes Scanpy-based spatial transcriptomic preprocessing, unsupervised Leiden clustering resolving 9 microenvironmental niches, differential marker profiling (DCN, THBS1, SPP1, S100A4, etc.), and high-resolution infographics detailing the dual-wave nanotherapeutic architecture, biocomputing logic gates, and ferroptosis-targeted payload release kinetics.
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Zenodo创建时间:
2026-08-09



