CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
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2020-10-08
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CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning [LAM-HTGTS]. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning [LAM-HTGTS]
RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells. Upon binding a recombination center (RC)-based JH, RAG scans upstream chromatin via loop extrusion, potentially mediated by
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Hairpin Forming Complex, RAG1/2-Nicked 12RSS/23RSS complex in Ca2+
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The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [ChIP-Seq]. The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [ChIP-Seq]
RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding ele
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Crystal structure of the RAG1 nonamer-binding domain with DNA
Crystal structure of the RAG1 nonamer-binding domain with DNA Descriptor: 5'-D(*AP*CP*TP*TP*AP*AP*CP*AP*AP*AP*AP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*TP*TP*TP*TP*GP*TP*TP*AP*AP*G)-3', V(D)J recombination-ac
Protein Data Bank Japan2024-02-21 更新40
The Nicking Step in V(D)J Recombination Is Independent of Synapsis: Implications for the Immune Repertoire
In all of the transposition reactions that have been characterized thus far, synapsis of two transposon ends is required before any catalytic steps (strand nicking or strand transfer) occur. In V(D)J
PubMed Central30



