Nuclear receptors (NRs) are ligand-activated transcription factors regulating a large variety of processes involved in reproduction, development, and metabolism. NRs are ideal drug targets. Immortaliz

NIAID Data Ecosystem60

Data_Sheet_1_Immune Factor, TNFα, Disrupts Human Brain Organoid Development Similar to Schizophrenia—Schizophrenia Increases Developmental Vulnerability to TNFα.pdf

精神分裂症神经发育机制

类器官模型

Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased tumor necrosis factor-α (TNF-α) may contribute. Previous studies using iPSC-derived

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Genetically defined human GBM organoids reveal principles of GBM development and actionable targets

胶质母细胞瘤

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Genetically defined human GBM organoids reveal principles of GBM development and actionable targets

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类器官模型

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We developed a method of generating human induced pluripotent stem cell (iPSC)-derived mesenchymal cells (iMES) that were able to induce AT1 and AT2 epithelial lineage cells in organoids. Transcriptom

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