Structure of MBP-Mcl-1 in complex with a macrocyclic compound
收藏Protein Data Bank Japan2026-03-04 更新2026-04-25 收录
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Structure of MBP-Mcl-1 in complex with a macrocyclic compound Descriptor: (7R,20P)-18-chloro-1-(4-fluorophenyl)-10-{[(2M)-2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-7,8,15,16-tetrahydro-14H-17,20-etheno-9,13-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Judge, R.A, Judd, A.S, Souers, A.J. Deposit date: 2022-09-22 Release date: 2023-10-04 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.917 Å) Cite: Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
创建时间：
2022-09-22
