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Eliminating non-autoreactive Antibody Accumulation Mitigates Duchenne muscular dystrophy

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP464414
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Importantly, by reducing such antibody accumulation via depleting B cells, we successfully alleviate muscular dystrophy and enhance muscle function in both murine and non-human primate (NHP) models of DMD. Our findings reveal a critical step in DMD pathogenesis and highlight the potential of targeting antibody accumulation as a promising therapeutic strategy for DMD treatment.
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2025-10-31
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