Therapeutic potential of hUC-MSCs in Alzheimer's Disease: linking neuropathological improvements with proteomics and microbiome insights

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integrated proteome resources2026-02-07 收录

阿尔茨海默病治疗

神经疾病多组学分析

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Therapeutic potential of hUC-MSCs in Alzheimer's Disease: linking neuropathological improvements with proteomics and microbiome insights

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Alzheimer's disease (AD) is defined neuropathologically by the abnormal accumulation of aggregated amyloid-beta (Aβ) peptides and tau that form extracellular and intracellular amyloid deposits, respectively. Inherited forms of AD (familial AD, FAD) are caused by autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 and PSEN2) genes. AD is marked by severe neuronal degeneration and depletion, primarily resulting from the overproduction of senile plaques composed of Aβ and the accumulation of hyperphosphorylated microtubule-associated protein tau (P-Tau) deposits. As the global population ages, the incidence of AD is increasing, placing a growing burden on societies and families. Current treatments for AD primarily offer symptomatic relief but fail to halt or reverse the disease's progression. Therefore, exploring novel therapeutic strategies is of paramount importance.

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2025-08-25

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