Summary of different physiological parameters analyzed in old Polμ−/− mice.

Numbers indicates the ratio KO/WT for each parameter. Footnotes.(a)Corresponding specifically to G2/M cells;(b)Evaluation of senescence ex vivo, at atmospheric concentration of O2;(c)Ploidy (≥4n) evaluation after PI staining;(d)Aneuploidy and translocation frequency evaluation;(e)Evaluated on CFU-GM progenitors;(f)Evaluated in cell lines;(g)ALT/GPT; AST/GOT; Billirubin and Albumin;(h)P-Hepatect. Recovery: partial hepatectomy recovery;(i)Protein carbonyls;(j)peroxided lipids;(k)Values obtained at atmospheric oxygen;(l)Paraquat Resistance, (70 mg/kg; ip);(m)Analysis of CHO-DN cell line, at atmospheric oxygen;(n)HR express. qRT-PCR analysis of selected functions involved in HR;(o)Tumor susceptibility. Evaluation of spontaneous tumor incidence and susceptibility to thymic lymphomas by low dose of radiation;(p)Evaluations in 129/BALBc and B6 backgrounds, respectively; Abbreviations: Thy, thymus; Sp, spleen; Br, brain, Sk, skin; Ov, ovary; Panc, Pancreas; PB, peripheral blood. Symbols; (++), (+), (+/−) and (−) indicates that values for KO animals were clearly higher, superior, similar and reduced, respectivelly, in comparison with control (wt) animals.